' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.8
USERS' SCORE
Very Good
Based on 57 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
8
Eicosapentaenoic Acid reduces heart risks
Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis.
High relevance to heart health
We evaluated the impact of eicosapentaenoic acid (EPA) on heart disease, specifically focusing on its potential to reduce the risk of sudden cardiac death (SCD) and cardiovascular mortality (CVD mortality). Through a systematic review and meta-analysis, we gathered insights from 10 prospective cohort studies involving a total of 310,955 participants over an average follow-up period of 8.7 years.
Our analysis revealed that higher levels of omega-3 fatty acids, including EPA, in the blood were associated with a lower risk of both SCD and CVD mortality. Specifically, we found that individuals with high circulating levels of EPA and other omega-3s had a significantly reduced hazard ratio of 0.55 for SCD compared to those with lower levels. This suggests a protective effect linked to increased EPA intake.
Furthermore, our sub-analysis indicated that higher percentages of EPA and another omega-3 called DHA in the blood also correlated with a reduced risk of adverse cardiac events. These findings highlight the promising role of EPA as a beneficial component in cardiovascular health strategies.
Overall, the evidence suggests that increasing our intake of EPA could serve as an effective measure to lessen the incidence of serious heart-related issues, making it a topic worth considering in future dietary recommendations.
Our analysis revealed that higher levels of omega-3 fatty acids, including EPA, in the blood were associated with a lower risk of both SCD and CVD mortality. Specifically, we found that individuals with high circulating levels of EPA and other omega-3s had a significantly reduced hazard ratio of 0.55 for SCD compared to those with lower levels. This suggests a protective effect linked to increased EPA intake.
Furthermore, our sub-analysis indicated that higher percentages of EPA and another omega-3 called DHA in the blood also correlated with a reduced risk of adverse cardiac events. These findings highlight the promising role of EPA as a beneficial component in cardiovascular health strategies.
Overall, the evidence suggests that increasing our intake of EPA could serve as an effective measure to lessen the incidence of serious heart-related issues, making it a topic worth considering in future dietary recommendations.
Read More
Most Useful Reviews
9.5
Cardiovascular benefits
"Mega" omega!!! This quality fish oil contains essential omega-3 fatty acids, which significantly lower cholesterol levels and aid in preventing heart disease. Omega-3 has been noted by oncologists for slowing tumour growth and is effective for various skin ailments. It also reduces allergy symptoms in children, aids in wound healing, and helps with arthritis by promoting anti-inflammatory prostaglandins. Omega-3 is vital for brain function and can help pregnant women develop the embryo. I take it daily to regulate fat metabolism and support overall health.
Read More
9
Strengthens heart health
Omega-3 is crucial for cell membrane strength and brain health. Regular inclusion of these fatty acids can reduce the risk of heart disease, lower blood pressure in hypertensives, and improve mental well-being. It also alleviates joint pain and skin issues. While omega-6 acids can be harmful in excess, omega-3 neutralises their negative effects. I prefer products that state "Omega-3" for higher benefits. This supplement is good value, with a substantial number of capsules, ideal for those who don’t consume enough fish.
Read More
9.5
Heart health improvement
After starting this omega-3, my heart issues have diminished. I recommend it for anyone experiencing similar challenges. If you found this helpful, please click "YES."
Read More
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.8
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
Eicosapentaenoic acid improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Directly studies heart failure treatment
We explored how eicosapentaenoic acid (a type of omega-3 fatty acid) can play a role in improving heart health, particularly in individuals with heart failure. Our analysis involved a network meta-analysis of numerous randomized controlled trials, focusing on the effects of eicosapentaenoic acid on heart function.
The findings showed that high doses of omega-3 supplements, specifically between 2000 to 4000 mg per day, taken for at least a year, can significantly enhance left ventricular ejection fraction, which is an important measure of heart function. This is encouraging news for patients struggling with heart failure, as a better ejection fraction can lead to improved heart health.
We also observed improvements in peak oxygen consumption, offering further evidence of how eicosapentaenoic acid can boost cardiac performance. Importantly, we found no significant increases in dropout rates or overall mortality among those taking omega-3 supplements compared to those not taking them. This suggests that the benefits come without added risks.
Overall, our research underscores the potential of long-term, high-dose eicosapentaenoic acid supplementation as a supportive treatment option for heart failure patients, advocating for further studies to confirm these promising results and help refine treatment recommendations.
The findings showed that high doses of omega-3 supplements, specifically between 2000 to 4000 mg per day, taken for at least a year, can significantly enhance left ventricular ejection fraction, which is an important measure of heart function. This is encouraging news for patients struggling with heart failure, as a better ejection fraction can lead to improved heart health.
We also observed improvements in peak oxygen consumption, offering further evidence of how eicosapentaenoic acid can boost cardiac performance. Importantly, we found no significant increases in dropout rates or overall mortality among those taking omega-3 supplements compared to those not taking them. This suggests that the benefits come without added risks.
Overall, our research underscores the potential of long-term, high-dose eicosapentaenoic acid supplementation as a supportive treatment option for heart failure patients, advocating for further studies to confirm these promising results and help refine treatment recommendations.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
9
Omega-3s and heart disease risk
Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies.
Considered broader omega-3 impacts
We explored the connection between omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), and coronary heart disease (CHD). Our analysis reviewed 36 observational studies that included both prospective and retrospective designs, offering a well-rounded look at how different omega-3 levels may impact heart health.
The results highlighted a clear trend: higher levels of various omega-3 fatty acids, including EPA, were associated with a reduced risk of developing CHD. We noted that groups with elevated omega-3 levels displayed lower relative risks—indicating that maintaining a sufficient intake of these fatty acids could be beneficial for heart health.
Interestingly, our findings revealed that patients with CHD had significantly lower omega-3 levels compared to healthier individuals. Moreover, specific subtypes of omega-3, such as EPA and DHA, demonstrated a particularly strong inverse relationship with both fatal and non-fatal heart disease events.
Overall, this analysis shows that omega-3 polyunsaturated fatty acids, especially EPA and DHA, are linked to a decreased risk of CHD. Our findings support the idea that integrating these nutrients into our diets may provide protective benefits against heart disease.
The results highlighted a clear trend: higher levels of various omega-3 fatty acids, including EPA, were associated with a reduced risk of developing CHD. We noted that groups with elevated omega-3 levels displayed lower relative risks—indicating that maintaining a sufficient intake of these fatty acids could be beneficial for heart health.
Interestingly, our findings revealed that patients with CHD had significantly lower omega-3 levels compared to healthier individuals. Moreover, specific subtypes of omega-3, such as EPA and DHA, demonstrated a particularly strong inverse relationship with both fatal and non-fatal heart disease events.
Overall, this analysis shows that omega-3 polyunsaturated fatty acids, especially EPA and DHA, are linked to a decreased risk of CHD. Our findings support the idea that integrating these nutrients into our diets may provide protective benefits against heart disease.
Read More
8
Cardiovascular benefits of eicosapentaenoic acid
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Study considers statin-treated patients
We explored the effectiveness of icosapent ethyl, a formulation of eicosapentaenoic acid, in reducing cardiovascular risks among patients who were already on statin therapy. The focus was on individuals with elevated triglyceride levels and low-density lipoprotein cholesterol (LDL-C) at a baseline of 41 to 100 mg/dL.
In this comprehensive analysis of the REDUCE-IT trial, we observed that patients were randomly assigned to receive either icosapent ethyl or a placebo, allowing for a clear comparison of results. The findings revealed that even those with well-controlled LDL-C levels, categorized as less than 55 mg/dL, exhibited significant benefits in cardiovascular outcomes when treated with icosapent ethyl.
Specifically, patients with LDL-C below 55 mg/dL experienced a notable reduction in primary cardiovascular events, with a reported decrease in rates from 22.8% to 16.2%. We also found similar outcomes in patients with LDL-C of 55 mg/dL or higher, further emphasizing the drug's potential effectiveness across different baseline cholesterol levels.
Overall, the study suggests that icosapent ethyl can confer cardiovascular benefits regardless of a patient's baseline LDL-C, indicating its importance in heart disease management, particularly for those at high cardiovascular risk.
In this comprehensive analysis of the REDUCE-IT trial, we observed that patients were randomly assigned to receive either icosapent ethyl or a placebo, allowing for a clear comparison of results. The findings revealed that even those with well-controlled LDL-C levels, categorized as less than 55 mg/dL, exhibited significant benefits in cardiovascular outcomes when treated with icosapent ethyl.
Specifically, patients with LDL-C below 55 mg/dL experienced a notable reduction in primary cardiovascular events, with a reported decrease in rates from 22.8% to 16.2%. We also found similar outcomes in patients with LDL-C of 55 mg/dL or higher, further emphasizing the drug's potential effectiveness across different baseline cholesterol levels.
Overall, the study suggests that icosapent ethyl can confer cardiovascular benefits regardless of a patient's baseline LDL-C, indicating its importance in heart disease management, particularly for those at high cardiovascular risk.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 57 Reviews
8.3
9.5
Cardiovascular benefits
"Mega" omega!!! This quality fish oil contains essential omega-3 fatty acids, which significantly lower cholesterol levels and aid in preventing heart disease. Omega-3 has been noted by oncologists for slowing tumour growth and is effective for various skin ailments. It also reduces allergy symptoms in children, aids in wound healing, and helps with arthritis by promoting anti-inflammatory prostaglandins. Omega-3 is vital for brain function and can help pregnant women develop the embryo. I take it daily to regulate fat metabolism and support overall health.
Read More
9.5
Heart health improvement
After starting this omega-3, my heart issues have diminished. I recommend it for anyone experiencing similar challenges. If you found this helpful, please click "YES."
9.5
Improved heart health
Natrol Omega-3 Fish Oil capsules are fairly large but effective. I've noticed significant benefits: my skin feels smoother, hair sheds less, and I wake up more refreshed. The packaging highlights heart health, and I genuinely hope it supports my cardiovascular system as claimed. Overall, this product is worthy of its positive reputation.
Read More
9.5
Family health boost
A friend recommended this omega-3, which we all take as a family. It helps in lowering 'bad' cholesterol and supports heart health. The capsules are pleasant and easy to swallow, unlike others we’ve tried. We have all benefitted from this product!
9.5
Muscle cramp relief
I've suffered from heart muscle cramps in my twenties and have taken this omega-3 for years. The pleasant lemon taste has effectively resolved these cramps, proving that Omega-3 genuinely supports heart health. Whenever I stop taking it, I can feel the impact.
